Cmv virus and breast cancer

Experimental vaccines are being tested for women of childbearing age. These vaccines may be useful in preventing CMV infection in mothers and infants, and reducing the chance that babies born to women who are infected while pregnant will develop disabilities.

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Overview Cytomegalovirus CMV is a common virus. Request an Appointment at Mayo Clinic. Share on: Facebook Twitter. Show references Bennett JE, et al. Cytomegalovirus CMV. Elsevier; Accessed Jan. Goldman L, et al. In: Goldman-Cecil Medicine.

Cytomegalovirus CMV infection. Merck Manual Professional Version. Kliegman RM, et al. In: Nelson Textbook of Pediatrics. Kimberlin DW, et al. Cytomegalovirus infection. Should HCMV persistently infect various human cancer types, it is possible that multiple viral-driven oncogenic mechanisms may potentially be involved.

Given the emerging nature of this field, the present group of articles will provide an overview of the epidemiological, pathological and therapeutic aspects relating to HCMV in human cancer. Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area!

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. This article has been cited by other articles in PMC. Abstract Findings of polymerase chain reaction PCR studies of cytomegalovirus CMV and Epstein-Barr virus EBV and breast cancer vary, making it difficult to determine whether either, both, or neither virus is causally associated with breast cancer.

Introduction Breast cancer is the most commonly diagnosed cancer in women worldwide. Table 1 Patient and tumour characteristics. Age of Patient at Surgery Percent 25—29 1. Open in a separate window.

Statistical analysis Random effects meta-analysis was performed on the proportions of samples positive for EBV and CMV respectively rather than relative risks, because only six studies including ours included paired normal samples. Results and Discussion The age range of the women studied was 25—88, with most in the 40—54 year age-group Table 1. Fig 1. Meta-analysis of EBV positivity in breast cancer tissue samples.

Fig 2. Meta-analysis of CMV positivity in breast cancer tissue samples. Table 4 Advantages and limitations of molecular analyses. Advantages Limitations Immunohistochemistry IHC Can distinguish virus in tumour cells from virus in other cells such as lymphocytes. In-situ hybridization ISH Can distinguish virus in tumour cells from virus in other cells such as lymphocytes. Southern Blot hybridization Permits semi-quantification of viral load. Cannot differentiate between cell types for instance in breast tumours with lymphocytic infiltrates.

Possibility of false positive results due to lytic viral replication. Prone to contamination for example by positive control DNA. PDF Click here for additional data file. Acknowledgments We acknowledge the women who donated tissue samples and the Cancer Society Tissue Bank Christchurch, for providing the samples for this study.

Data Availability All relevant data are within the paper and its Supporting Information files. References 1. Global cancer statistics.

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Cytomegalovirus, Epstein-Barr virus and risk of breast cancer before age 40 years: a case-control study. Br J Cancer.

Breast cancer, cytomegalovirus and Epstein-Barr virus: a nested case-control study. British Journal of Cancer. Soderberg-Naucler C. HCMV microinfections in inflammatory diseases and cancer. Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology.

The story of human cytomegalovirus and cancer: increasing evidence and open questions. Soroceanu L, Cobbs CS. Is HCMV a tumor promoter? Virus Research. Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. Journal of Clinical Investigation. Association of viral factors with non-familial breast cancer in Taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues.

Journal of medical virology. Relationship between viral factors, axillary lymph node status and survival in breast cancer. J Cancer Res Clin Ocol. Detection of human cytomegalovirus in normal and neoplastic breast epithelium.

Detection of Epstein-Barr virus in invasive breast cancers. Journal of the National Cancer Institute. Magrath I, Bhatia K. Breast cancer: a new Epstein-Barr virus-associated disease? J Natl Cancer Inst. Frequency and genome load of Epstein-Barr virus in breast cancers from different geographical areas.

Hermann K, Niedobitek G. Lack of evidence for an association of Epstein-Barr virus infection with breast carcinoma. Epstein-Barr virus gene expression in human breast cancer: protagonist or passenger? Epstein-Barr virus and breast cancer: serological study in a high-incidence area of nasopharyngeal carcinoma. Cancer letters. Epstein-Barr virus as a marker of biological aggressiveness in breast cancer. Incidence of de-novo breast cancer in women chronically immunosuppressed after organ transplantation.

The Lancet. Breast cancer and microbial cancer incidence in female populations around the world: A surprising hyperbolic association. International Journal of Cancer. Risk of Hodgkin's disease and other cancers after infectious mononucleosis.

The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress. Activation of telomerase by human cytomegalovirus. Apr 1; 7 — Analysis of Epstein-Barr virus reservoirs in paired blood and breast cancer primary biopsy specimens by real time PCR.

Breast cancer research: BCR. Lack of association between EBV and breast carcinoma. Localization of Epstein-Barr virus to infiltrating lymphocytes in breast carcinomas and not malignant cells.

Experimental and molecular pathology.